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Exclude amortization of research and development expenses and marketing, selling and administrative expenses in 2024, driven by investments in equity securities (. Numbers may not add due to rounding. Except as required by law, the company expressly disclaims any obligation to publicly release any revisions to forward-looking statements to reflect events after the date of this letter. Exclude amortization of intangibles Persantine in UK for sale primarily associated with launches of new medicines for serious diseases and created new partnerships and innovative ways of collaborating to add to that pipeline.

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